Sunday, September 30, 2012

'Hotel Transylvania' checks in with $43M debut

This image released by Sony Pictures shows Dracula, voiced by Adam Sandler, in a scene from "Hotel Transylvania." (AP Photo/Sony Pictures Animation)

This image released by Sony Pictures shows Dracula, voiced by Adam Sandler, in a scene from "Hotel Transylvania." (AP Photo/Sony Pictures Animation)

(AP) ? Adam Sandler's monster mash-up "Hotel Transylvania" has brought the weekend box office back to life after a late-summer slump.

The animated comedy from Sony Pictures debuted at No. 1 with $43 million, one of the strongest starts ever for a movie opening in September, according to studio estimates Sunday.

"Hotel Transylvania" set a new high for September debuts in terms of actual dollars, beating the previous record of $35.7 million for 2002's "Sweet Home Alabama." But factoring in today's higher admission prices, "Sweet Home Alabama" sold more tickets.

This weekend's box office was further strengthened by a solid No. 2 debut for another Sony release, Bruce Willis and Joseph Gordon-Levitt's time-travel thriller "Looper," which took in $21.2 million.

Hollywood's overall grosses rose for the first time in a month compared to the same weekend last year. Revenues totaled $120 million, up 21 percent from the same weekend a year ago, when "Dolphin Tale" led with $13.9 million, according to box-office tracker Hollywood.com.

"Sony really kind of saved the day here, turning things around after a full month of less-than-stellar box office," said Hollywood.com analyst Paul Dergarabedian. "The post-summer period didn't exactly set the world on fire."

It's rare for one studio to open two wide releases over the same weekend, but Sony had two movies that complemented each other well without overlapping their audiences.

Locking up the family crowds, the PG-rated "Hotel Transylvania" features Sandler providing the voice of Count Dracula as proprietor of a resort catering to Frankenstein, the Wolfman and other monsters.

The R-rated "Looper" pulled in male action fans. Set in 2044, the film stars Gordon-Levitt as a hit man assigned to kill victims sent back in time ? including his future self (Bruce Willis).

The previous weekend's No. 1 movie, Open Road Films' police story "End of Watch," fell to No. 3 with $8 million, raising its domestic total to $26.2 million.

In narrower release, Universal Pictures' music tale "Pitch Perfect" opened strongly at No. 6 with $5.2 million. The movie stars Anna Kendrick as a college freshman who joins an a cappella singing team and livens up the group's conservative style.

Playing in 335 theaters, "Pitch Perfect" averaged an impressive $15,560 a cinema. That compared to an average of $12,840 in 3,349 theaters for "Hotel Transylvania" and $7,086 in 2,992 cinemas for "Looper."

The weekend's other new wide release, Maggie Gyllenhaal and Viola Davis' school drama "Won't Back Down," flopped at No. 10 with $2.7 million, averaging just $1,074 in 2,515 theaters. The movie centers on two mothers who organize a campaign to save a failing elementary school.

For Sandler, "Hotel "Transylvania" was a return to hit status after his summer dud "That's My Boy" and so-so results on last year's comedy "Jack and Jill."

Sandler's audience of young males generally has waned as he ages. But Sony, which has released most of his movies, remains eager to stay in the Sandler business.

"I have said that many times, and it still holds in a big way," said Rory Bruer, head of distribution for Sony.

Estimated ticket sales for Friday through Sunday at U.S. and Canadian theaters, according to Hollywood.com. Where available, latest international numbers are also included. Final domestic figures will be released Monday.

1. "Hotel Transylvania," $43 million ($8.1 million international).

2. "Looper," $21.2 million ($8.5 million international).

3. "End of Watch," $8 million.

4. "Trouble with the Curve," $7.5 million.

5. "House at the End of the Street," $7.2 million ($1.5 million international).

6. "Pitch Perfect," $5.2 million.

7. "Finding Nemo," $4.1 million ($1.1 million international).

8. "Resident Evil: Retribution," $3 million ($20.7 million international).

9. "The Master," $2.75 million.

10. "Won't Back Down," $2.7 million.

___

Estimated weekend ticket sales at international theaters (excluding the U.S. and Canada) for films distributed overseas by Hollywood studios, according to Rentrak:

1. "Resident Evil: Retribution," $20.7 million.

2. "Ted," $9.1 million.

3 (tie). "Masquerade," $9 million.

3 (tie). "Les Seigneurs," $9 million.

5. "Ice Age: Continental Drift," $8.7 million.

6. "Looper," $8.5 million.

7. "Hotel Transylvania," $8.1 million.

8. "The Bourne Legacy," $7.7 million.

9. "Taken 2," $6.4 million.

10. "Madagascar 3: Europe's Most Wanted," $6.1 million.

___

Online:

http://www.hollywood.com

http://www.rentrak.com

___

Universal and Focus are owned by NBC Universal, a unit of Comcast Corp.; Sony, Columbia, Sony Screen Gems and Sony Pictures Classics are units of Sony Corp.; Paramount is owned by Viacom Inc.; Disney, Pixar and Marvel are owned by The Walt Disney Co.; Miramax is owned by Filmyard Holdings LLC; 20th Century Fox and Fox Searchlight are owned by News Corp.; Warner Bros. and New Line are units of Time Warner Inc.; MGM is owned by a group of former creditors including Highland Capital, Anchorage Advisors and Carl Icahn; Lionsgate is owned by Lions Gate Entertainment Corp.; IFC is owned by AMC Networks Inc.; Rogue is owned by Relativity Media LLC.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2012-09-30-Box%20Office/id-feacb3ffc9a245b883362bbdbd2e26b3

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The Search For Minority Entrepreneurs Is Over ? Now They Need To Be Ready For Investors

minority-ntrepreneursEditor?s note: Wayne Sutton is the founder and CEO of?PitchTo, a mobile development lab that builds tools for investors to make smarter decisions and help entrepreneurs deliver exceptional pitches. This article is inspired by Dave McClure?s ?Women in Tech: Put Your Money Where Your Mouth Is.? post. Follow Wayne on Twitter.? What a difference a year makes. Last year the question was ?Where are the minority entrepreneurs?? It was highly motivated by the 2010 CBinsights Venture Capital Human Capital Report, which stated that only 1 percent of minority tech startup founders were founded by African-Americans. But the conversation about minority entrepreneurs didn?t only apply to African-Americans, it also included women and Hispanics. The dialogue reached its peak by various snippets from the CNN?s ?Black in America 4? documentary and niche tech blogs.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/-TTtmyo93Y0/

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Saturday, September 29, 2012

Sony Xperia Tablet S gets chunky update: better multi-tasking and IR, guest mode, new media apps

Sony Xperia Tablet S gets chunky update better multitasking and IR, guest mode, new media apps

The original Tablet S absorbed a few interesting updates in its time and hopefully things will go the same way with its slimmed-down replacement -- the Xperia Tablet S. It's getting off to a good start, with devices already waking up to an Android 4.0.3 update that brings significant additions like a Guest Mode for creating restricted user accounts, revampled media and social aggregation apps, and six assignable macro buttons on the IR Remote Control app. Sony has also bolstered its Small Apps function, allowing you to overlay a browser, IR remote and other utilities in a window on top of another app. What this update isn't is the promised switch to Jelly Bean, of course, but it might just help to tide you over in the meantime.

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Google Launches A New Tablet-Optimized User Interface For Flight Search

Google logo 215Google just announced an update to its Flight Search feature that makes it easier for tablet users to search for and book travel from their couch. According to a recent study, 47% of all U.S. tablet owners who search for travel on their tablets also end up purchasing via them. Starting today, travelers who use their iPads or Nexus 7s to use Flight Search will get to see this new tablet-optimized user interface.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/P-DXCRtbqkk/

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Williamsburg, Classes, Activities, Recreational Sports, Art, Dance ...

?

Register for Youth Basketball Today!

?

Online registration will end at midnight on Sunday, September 30th. You can register on our website at www.williamsburgva.gov/rec.

Registration will accepted in person at the Quarterpath Recreation Center, 202 Quarterpath Road during the following hours:

  • Friday, September 28th until 9:00 p.m.
  • Saturday, September 29th from 9:00 a.m. until 6:00 p.m.
  • Sunday, September 30th from 1:00 p.m. until 8:00 p.m.
  • Monday, October 1st from 8:00 a.m. until 9:00 p.m.
Starting Tuesday, October 2nd, names will be place don the wait list for Boys 6 to 12 and Girls 6 to 13. We will continue to take registration for Boys 13 to 17 until November 19th.

If you have any questions, please call (757) 259-3760 and a Recreation Associate will assist you. We look forward to assisting you with your registration needs!

If you have already registered, thank you for participating and we look forward to a basketball season this year!

Source: http://williamsburgfamiliessports.blogspot.com/2012/09/youth-basketball-registration.html

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Friday, September 28, 2012

Lexus LF-CC Concept shows the future of touchscreen interiors ...

WORLD PREMIERE OF THE LEXUS LF-CC CONCEPT CAR AT THE 2012 PARIS MOTOR SHOW
LF-CC displays the latest evolution of the L-finesse design language and signature spindle grille, to be reflected in future Lexus D-Segment vehicles
Announces the market launch of a mid-size coupe in the near future
Features a new 2.5 litre full hybrid powertrain with class-leading CO2 emissions, which will be introduced soon in the Lexus model range

Brussels, Belgium - Following the unveiling of Lexus' award-winning hybrid 2+2 sports coupe concept, the LF-LC at the 2012 Detroit Motor Show and its European debut at the Geneva Motor Show, a new, mid-sized coupe concept, the LF-CC makes its World Premiere at the 2012 Paris Motor Show.
The more compact, rear-wheel drive, full hybrid LF-CC already integrates various design cues from the LF-LC; a first illustration of how concept cars are truly influencing future Lexus models and, in this instance, future D-Segment derivatives.
Announcing the launch of a premium mid-sized coupe in the more accessible D-segment in the near future, the LF-CC reinforces Lexus' commitment to create more engaging, inspirational vehicles through attractive design, a superior driving experience and advanced technologies.

EXTERIOR DESIGN
The LF-CC showcases the latest evolution of the company's unique L-finesse design language, with the boldest yet interpretation of the signature Lexus 'spindle' grille. Framed by the bonnet lip, deep lower spoiler and powerfully projecting front fender tips, the grille mesh is encased in a deep, metal-finish surround and takes on a pronounced, 3D form.
A unique, 3 LED-projector headlamp design is housed in the narrow gap between the lower and upper fender surfaces, without a conventional, one-piece cover. Independent Daytime Running Lights (DRLs) are fully integrated into the upper bumper surface to complete this unique new design.
The broad lower fenders are aerodynamically sculpted to manage the flow of air to the engine bay and front brakes, whilst reinforcing the powerful, dynamic road presence of the new Lexus signature frontal design.
In profile, the powerful convex curve of the bonnet flows seamlessly through a steeply raked windscreen into a roofline which deliberately peaks towards the rear of the cabin to emphasise the traction available from the vehicle's rear-wheel drive powertrain.
The bodywork is stretched tight between the front and rear fenders, and the rear fender is less pronounced than that of the front, reinforcing the concentration of vehicle weight over the driven wheels for maximum traction.
Further developing a design form initiated on the LF-LC concept and the high-performance LFA, the sharply sculpted form of an airflow regulating fin flows from underneath the side of the car and upwards through the rear wheel arch. This aerodynamic detail is designed to increase downforce over the driven wheels, further improving traction.
The airflow regulating fin merges with the falling roofline in a pronounced rear spoiler integrated within the boot lid, seamlessly fusing design and aerodynamic elements to give the vehicle its distinctive, coupe proportions.
To the rear, the full width bumper flows into the rear wheel arches to emphasise the LF-CC's broad, powerful stance. Lexus-characteristic L-shaped combination lamps feature a layered, strongly three-dimensional design, and the lower, concave bumper section incorporates a full width spoiler to further enhance rear-wheel drive traction. The rear stop lamp is nicely integrated into the shark antenna.
The LF-CC is finished in a new, 'Fluid Titanium' exterior colour, a metallic finish with exceptionally high brilliance which combines sharp, bright highlighting with dark shaded surfaces to reinforce the powerful forms of the bodywork's sculpted surfaces.

INTERIOR DESIGN
The LF-CC's interior hints at the progressive luxury of a future Lexus model cabin layout, and represents a further development of the company's HMI (Human Machine Interface) design philosophy.
The dashboard is divided into two distinct zones: an upper, Display Zone, with a multi-display screen located at an ideal distance for at-a-glance viewing, and a lower, Operation Zone, which allows access to the uniquely designed shift lever and an innovative touch tracer display for remote system control.
This clear division of zones creates a unique fusion of an airy, spacious cabin and a sporting cockpit which places the emphasis on a snug, highly focused driving environment. All functional driving components are consolidated in the driver's seat surroundings, combining outstanding ergonomics with advanced HMI technologies.
The driver benefits from a low, highly focused driving position with a sporting, wide grip steering wheel, optimum pedal placement and high-visibility instrument dials. The touch tracer display for remote system control is located directly behind the shift lever for maximum comfort and ease of operation.
Coordinating with the 'Fluid Titanium' exterior colour, the seats, door panels and instrument binnacle hood are trimmed in a warm, elegant amber leather finish. The extensive use of metallic finishes and soft touch materials throughout reinforces the premium quality of the environment. The contrast between the exterior and interior colour schemes gives the car an elegant yet simultaneously sporting image.

ALL-NEW 2.5 LITRE FULL HYBRID POWERTRAIN
Representing a new Lexus powertrain for future production, the LF-CC is equipped with an all-new, highly efficient, 2.5 litre full hybrid powertrain delivering a combination of the engaging performance appropriate to a sporting, D-segment coupe and low CO2 emissions, targeted below 100 g/km. This powertrain will achieve class-leading energy efficiency, with more than 2 hp produced per gram of CO2.
This Lexus Hybrid Drive powertrain features an all-new, ultra-smooth running, 2.5 litre 4-cylinder petrol engine mated to a compact, high-output, water-cooled permanent magnet electric motor.
In addition to the petrol engine and electric motor, the LF-CC hybrid drive system further comprises a generator, a high-performance battery, a power split device which, via planetary reduction gears, combines and re-allocates power from the engine, electric motor and generator according to operational requirements, and a compact power control unit to govern the high speed interaction of the system components.
Adapted specifically for the hybrid powertrain, the all-new 2.5 litre, DOHC, 4-cylinder petrol engine benefits from several technical improvements. It adopts the Atkinson cycle and D-4S direct injection technology to optimise both the power and fuel-efficiency benefits of Lexus Hybrid Drive.
Lexus will introduce this new hybrid powertrain into its model range in the near future.

LEXUS AT THE 2012 PARIS MOTOR SHOW
Besides the world premiere of the new LF-CC, Lexus will also display the all-new LS 600h F SPORT in Western European premiere. The new LS flagship sedan reflects the bolder Lexus exterior and interior design direction, and brings enhanced driving dynamics, world-leading refinement, luxury and innovative advanced technology.

Introduced by Paul Van der Burgh, Director Lexus Europe, the Lexus Press Conference will be held at 8.45 AM CET on September 27 (hall 4, stand 120).

Source: http://www.engadget.com/2012/09/27/lexus-lf-cc-concept-shows-the-future-of-touchscreen-interiors/

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Czech central bank cuts rates to record low as expected

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Thursday, September 27, 2012

Camera-equipped helmet gives you superhuman vision

7 hrs.

If you think of high dynamic range imaging, or HDR, you probably think of crazy panoramic?cityscapes or lighthouses where everything pops with impossible clarity ? imagine seeing the whole world that way.?These goggles let you look at everything in real-time 3-D HDR?? and it's more useful than you might think.

The HDRchitecture?project, by researchers at the University of Toronto, was presented earlier this month at the SIGGRAPH imaging convention in Los Angeles.

The most dramatic application the team could think of for showing off the capabilities of their system was welding, where the light from the torch is so bright that it can blind the welder if he doesn't wear a?leaded-glass visor. Unfortunately, this renders the rest of the world, including his immediate surroundings, quite dark. What if you could combine the two images ? the dark one that shows the torch clearly, and the light one that shows everything else?

Think of high dynamic range as wearing night-vision goggles and sunglasses at the same time, with none of the downsides.?You can see?highlights and shadows that would be blown out or too dark to see otherwise.?

To achieve this,?the team's?EyeTap helmet uses a pair of cameras?take?multiple exposures of the same view and combine them in real time, in such a way that no part is too dark and no part is?too light.?

As you can see in the video, that means that the welder can clearly see not only the super-bright torch, but the hot metal it's touching and the rest of the object as well. This could greatly improve not just the quality of the welder's work, but the safety of his workshop.

The video below demonstrates the futuristic-looking helmet in a few situations; there's a good comparison at 1:45, and more everyday situations towards the end.

It's not just for welders. If the technology were developed, a driver would never be blinded by the glare of the sun, and a soldier would never miss a mine hiding in a shadow. The possibilities are really very exciting.

Of course, the device itself will have to be adapted somewhat before you can wear it in the car; it's clearly a bit bulky at the moment. But this "mediated reality," as the narrator describes it, is potentially very powerful. More information and much supporting documentation can be found at the EyeTap site, or at Road to VR.

Devin Coldewey is a?contributing writer for NBC News Digital. His personal website is?coldewey.cc.

Source: http://www.nbcnews.com/technology/futureoftech/camera-equipped-high-dynamic-range-helmet-gives-you-superhuman-vision-6126562

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Google Maps Street View dives under the waves

Android Central

Do you ever have that moment where you're scuba diving in the south Pacific, and you're wondering "Was I supposed to turn right at the coral reef to get back to the resort, or keep swimming straight?" It happens to me all the time. Luckily Google, as ever, has us covered. The Google Maps team has just released a handful of new Street View locations that are underwater. Various spots along the coast of Australia, the Philippines, and Hawaii can take you down to see some of the wonderful aquatic landscape, wildlife, and flora in the region. You can find some of the more spectacular shots in Google's Street View gallery for the ocean

Looking at stuff like this, it's hard to imagine how iOS or Microsoft intend to outpace Google's progress in the mapping world. Sure, the underwater Street View is more for sightseeing than anything else, but the lengths Google is willing to go for completeness are pretty crazy. 

Any divers in the house? Ever wish you had a waterproof phone with you? 

Source: Google Lat Long



Source: http://feedproxy.google.com/~r/androidcentral/~3/vMl3BS3T2ME/story01.htm

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Duke Medicine news -- Protein structure unlocks 1 mystery of multi-drug tolerance

Duke Medicine news -- Protein structure unlocks 1 mystery of multi-drug tolerance [ Back to EurekAlert! ] Public release date: 26-Sep-2012
[ | E-mail | Share Share ]

Contact: Sarah Avery
sarah.avery@duke.edu
919-660-1306
Duke University Medical Center

DURHAM, N.C. The structures of key bacterial proteins have revealed one of the biochemical secrets that enables bacteria to outwit antibiotics.

In a paper published Sept. 20, 2012 in the journal Cell Reports, Duke University School of Medicine researchers and their colleagues describe the results of a series of experiments exploring multi-drug tolerance, a phenomenon that allows bacteria to become dormant and tolerate antibiotics, only to later awaken and re-infect the host. Drug tolerance is a factor in several types of stubborn, recurring infectious diseases caused by pathogenic bacteria, such E. coli, P. aeruginosa and M. tuberculosis.

"One in a million of those bacteria can become dormant for reasons we don't yet fully understand," said senior author Richard G. Brennan, Ph.D., professor and chairman of Duke's Department of Biochemistry. "And when bacteria are dormant, drugs are far, far less effective in the eradication of infection."

Multi-drug tolerance begins with a protein kinase molecule called HipA, which drives a few bacterial cells into dormancy. Eventually, these so-called "persister" cells literally one in a million in the bacterial population awaken to begin growing and starting the cycle of infection all over again.

"It's a very clever thing for them to do, and it's one of the underlying reasons there are so many recalcitrant infections," said Maria A. Schumacher, Ph.D., professor of biochemistry at Duke and lead author of the study.

By analyzing the structural and biochemical components at work in the HipA-mediated system, the team was able to get to the bottom of how this protein works. Schumacher, the lead structural biologist in the group, used X-ray crystallography to produce an atomic-level three-dimensional structure of HipA. This structure was pivotal to understand how this simple modification affected HipA's activity.

"This protein carries out a process called phosphorylation, which affects the activities of other molecules that control dormancy," Schumacher said. "However, too much phosphorylation by HipA is likely a very bad thing for the cell, so HipA turns itself off by an unusual self-modification, which causes the modified region to become completely disordered. In fact, this normally internal part of the protein is ejected to the outside. To the best of our knowledge, this had never been seen before in any protein of this type, and it's an incredibly unusual mechanism for how it works. From a structural biology standpoint, it's a really exciting finding."

Multi-drug tolerance is not the same as the better-known state called multi-drug resistance.

"In multi-drug resistance, bacteria evolve by a number of mechanisms to become strains that are resistant to higher and higher concentrations of antibiotics," Brennan explained. "In multi-drug tolerance, the drugs don't work because the bacteria are dormant. The persister cells simply evade most drugs until it is safe for them to re-emerge and re-infect, without having mutated."

The next steps for the researchers will be to continue their structural and biochemical studies to better understand the multiple targets of the HipA protein in the cell, and how persistence is spread throughout the cell, perhaps by multiple proteins beyond just HipA. Eventually, a highly targeted drug therapy may be in sight.

"We can see how we might be able to inhibit the protein and shut down multi-drug tolerance, at least in these types of bacteria," said Brennan.

To Schumacher and Brennan, the study is an excellent example of why basic science is important for improving clinical care and developing treatments. "This is a perfect study to show how something we're doing that is very basic can have a downstream impact upon how we think about disease and disease treatments," Brennan said.

###

Other authors include JungKi Min, and Ziqiang Guan of the Duke Department of Biochemistry; Todd M. Link, Young-Ho Ahn, Jonathan M. Kurie and Weijun Xu of the University of Texas MD Anderson Cancer Center; Erik J. Soderblom and M. Arthur Moseley of the Duke Proteomics Core Facility, Institute for Genome Sciences & Policy; Artem Evdokimov of Monsanto, St. Louis; and Kim Lewis of Northeastern University.



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Duke Medicine news -- Protein structure unlocks 1 mystery of multi-drug tolerance [ Back to EurekAlert! ] Public release date: 26-Sep-2012
[ | E-mail | Share Share ]

Contact: Sarah Avery
sarah.avery@duke.edu
919-660-1306
Duke University Medical Center

DURHAM, N.C. The structures of key bacterial proteins have revealed one of the biochemical secrets that enables bacteria to outwit antibiotics.

In a paper published Sept. 20, 2012 in the journal Cell Reports, Duke University School of Medicine researchers and their colleagues describe the results of a series of experiments exploring multi-drug tolerance, a phenomenon that allows bacteria to become dormant and tolerate antibiotics, only to later awaken and re-infect the host. Drug tolerance is a factor in several types of stubborn, recurring infectious diseases caused by pathogenic bacteria, such E. coli, P. aeruginosa and M. tuberculosis.

"One in a million of those bacteria can become dormant for reasons we don't yet fully understand," said senior author Richard G. Brennan, Ph.D., professor and chairman of Duke's Department of Biochemistry. "And when bacteria are dormant, drugs are far, far less effective in the eradication of infection."

Multi-drug tolerance begins with a protein kinase molecule called HipA, which drives a few bacterial cells into dormancy. Eventually, these so-called "persister" cells literally one in a million in the bacterial population awaken to begin growing and starting the cycle of infection all over again.

"It's a very clever thing for them to do, and it's one of the underlying reasons there are so many recalcitrant infections," said Maria A. Schumacher, Ph.D., professor of biochemistry at Duke and lead author of the study.

By analyzing the structural and biochemical components at work in the HipA-mediated system, the team was able to get to the bottom of how this protein works. Schumacher, the lead structural biologist in the group, used X-ray crystallography to produce an atomic-level three-dimensional structure of HipA. This structure was pivotal to understand how this simple modification affected HipA's activity.

"This protein carries out a process called phosphorylation, which affects the activities of other molecules that control dormancy," Schumacher said. "However, too much phosphorylation by HipA is likely a very bad thing for the cell, so HipA turns itself off by an unusual self-modification, which causes the modified region to become completely disordered. In fact, this normally internal part of the protein is ejected to the outside. To the best of our knowledge, this had never been seen before in any protein of this type, and it's an incredibly unusual mechanism for how it works. From a structural biology standpoint, it's a really exciting finding."

Multi-drug tolerance is not the same as the better-known state called multi-drug resistance.

"In multi-drug resistance, bacteria evolve by a number of mechanisms to become strains that are resistant to higher and higher concentrations of antibiotics," Brennan explained. "In multi-drug tolerance, the drugs don't work because the bacteria are dormant. The persister cells simply evade most drugs until it is safe for them to re-emerge and re-infect, without having mutated."

The next steps for the researchers will be to continue their structural and biochemical studies to better understand the multiple targets of the HipA protein in the cell, and how persistence is spread throughout the cell, perhaps by multiple proteins beyond just HipA. Eventually, a highly targeted drug therapy may be in sight.

"We can see how we might be able to inhibit the protein and shut down multi-drug tolerance, at least in these types of bacteria," said Brennan.

To Schumacher and Brennan, the study is an excellent example of why basic science is important for improving clinical care and developing treatments. "This is a perfect study to show how something we're doing that is very basic can have a downstream impact upon how we think about disease and disease treatments," Brennan said.

###

Other authors include JungKi Min, and Ziqiang Guan of the Duke Department of Biochemistry; Todd M. Link, Young-Ho Ahn, Jonathan M. Kurie and Weijun Xu of the University of Texas MD Anderson Cancer Center; Erik J. Soderblom and M. Arthur Moseley of the Duke Proteomics Core Facility, Institute for Genome Sciences & Policy; Artem Evdokimov of Monsanto, St. Louis; and Kim Lewis of Northeastern University.



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Source: http://www.eurekalert.org/pub_releases/2012-09/dumc-dmn092612.php

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Wednesday, September 26, 2012

Hot Mama! Snooki Shows Off Her Post-Baby Body

Snooki shares her first full-body photo since giving birth! Plus, check out more stars' cute, candid and crazy Twitter photos

Source: http://www.ivillage.com/celebrity-twitter-pictures/1-b-229669?dst=iv%3AiVillage%3Acelebrity-twitter-pictures-229669

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Piers Morgan-Mahmoud Ahmadinejad CNN Interview - Business ...

CNN

Iranian President?Mahmoud Ahmadinejad?sat down with CNN's Piers Morgan Monday night, where the topics of conversation in a lengthy, wide-ranging interview ranged from his refusal to acknowledge the Holocaust to his views on homosexuality.?

Ahmadinejad continued to fan the flames of outrage by deciding to not acknowledge the occurrence of the Holocaust.?

"Whatever event has taken place throughout history, or hasn't taken place, I cannot judge that. Why should I judge that? I say researchers and scholars must be free to conduct research and analysis about any historical event," Ahmadinejad said.

Morgan asked him about a controversial comment he once made ? that Israel should be "wiped off" the map.?

"If a group comes and occupies the United States of America, destroys homes while women and children are in those homes, incarcerate the youth of America, impose five different wars on many neighbors, and always threaten others, what would you do? What would you say? Would you help it? ... Or would you help the people of the United States?" Ahmadinejad said.?

"So when we say 'to be wiped,' we say for occupation to be wiped off from this world. For war-seeking to (be) wiped off and eradicated, the killing of women and children to be eradicated. And we propose the way. We propose the path. The path is to recognize the right of the Palestinians to self-governance."

Later, the conversation turned to social issues:

"You are a father of three children," Morgan said, as part of a "lively" debate on homosexuality. "You have two sons and a daughter. What would you do if one of them was gay?"

"Proper education must be given," Ahmadinejad said. "The education system must be revamped. The political system must be revamped. But if a group recognizes an ugly behavior or ugly deed as legitimate, you must not expect other countries or other groups to give it the same recognition."

Ahmadinejad is in New York to address the U.N. General Assembly on Wednesday.

Watch the CNN clips below:

Source: http://www.businessinsider.com/piers-morgan-mahmoud-ahmadinejad-cnn-interview-2012-9

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Is AWeber The Best Autoresponder Service? An AWeber Review ...

Internet-and-Businesses-Online:Autoresponders Articles from EzineArticles.com

Is AWeber The Best Autoresponder Service? An AWeber Review

When it comes to building a profitable relationship with customers, email marketing is not only the best way to stay in touch, and is relatively inexpensive as well. I?ve experimented with literally dozens of scripts, contact forms, capture engines and auto-responder services, both hosted on my server and third-party servers.

Internet-and-Businesses-Online:Auctions Articles from EzineArticles.com

Tips On Beginning An eBay Store

Taking advantage of the many selling on eBay tips that are out there will help you to learn more about how to begin an eBay store of your own. The start up process is not difficult at all.

Computers-and-Technology:Certification-Tests Articles from EzineArticles.com

How to Win a Software Testing Campaign the Sun Tzu Way

It is very surprising to hear how many ?test professionals? engage in software testing without a test strategy. Often we come across QA professionals preaching that they will test everything to ensure quality and bug free systems. Digging into the idea of testing everything, it is common to observe that many test efforts are focused on working with business users to create detailed business oriented test scripts- happy path testing with limited success.

Source: http://www.cursebuster.vpanelhosting.net/wordpress/?p=2209

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Source: http://stephan-tumulus.blogspot.com/2012/09/is-aweber-best-autoresponder-service.html

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Source: http://thomaslyle54.typepad.com/blog/2012/09/is-aweber-the-best-autoresponder-service-an-aweber-review.html

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Tuesday, September 25, 2012

Debilitating Anxiety, TransDance California and The Great American ...

A little collaboration with DZ:

The Opinionator?s Anxiety series continues to impress! Its most recent installment, ?America the Anxious? by Ruth Whippman, is a Brit?s perspective on the American fixation on happiness, or at least, happiness-language. As a jumping off point, Whippman talks about the palpable differences between the Facebook feeds of her friends on either side of the Atlantic. While her British friends are often dismissively even-keel about their daily lives, her American friends are perpetually fitting the narrative of their days into the rubric of (capital H) Happiness.

Whippman goes on to frame Happiness as America?s Greatest Commandment, the declarative birthright of citizenship that, if left unpursued, is about as unAmerican as cricket. It is, for us, the only achievement that matters, the one that trumps all others. We will travel the map for experiences that bring ?happiness.? We will scoff at neighbors making more money than us, confident that they are not ?happy.? And we will post photos and tweets by the minute to prove that we are. It is no secret that the United States is the wealthiest country with the most worries, the richest in opportunities but poorest in satisfaction, predominantly because?as Whippman says in perfect Law-conscious psychology?our pursuit of happiness actually deters it. In the pursuit of ?Happiness in a Vacuum,? our end has demolished the means.

This is something we talk about a lot on Mockingbird, how the self-orientation implicit in personal pursuits of happiness precludes its attainment, that well-being cannot be ?approached directly,? etc. But this doesn?t mean we are somehow poo-poo-ing happiness (or social media as such). I mean, who doesn?t want to be happy? Happiness a good thing(!), and Lord knows we could all stand to experience a little more of it. And wallowing in misery isn?t good for anyone. The rubber meets the road, as it invariably does, when it comes to the how of happiness. In other words, does the imperative to be happy serve those who are unhappy (i.e. everyone)? Is it a crucial articulation of a noble priority/inalienable right? Or does it actually work against us, making us less happy and more anxious, as Whippman (and St. Paul) suggests? Indeed, the studies show?and the Bible tells us?that we happier the less we are thinking about ourselves and our relative happiness (or lack thereof). Blessed self-forgetfulness and all that. Of course, to limit this problem to Americans is ultimately a bit silly, as a preoccupation with one?s own well-being seems to be a universal human trait. The volume may be turned up in our little corner of the world?causing a bit more psychic fallout perhaps?but that doesn?t mean we have a monopoly on the issue.

Interestingly enough, Whippman points to the reality of true joy, and that it only ever occurs when expectation and pressure are removed; which means it is often only noticed retrospectively and freely. While the pursuit of happiness is ?nail-biting work,? the good fruit of joy (or, as she calls it, ?real happiness?) is the by-product of a life bereft of conditionality and comparative ?stacking up.? The answer to this kind of stacking up before an immeasurable measure of Happiness? Whippman?s last line says it all: ?Might as well stop trying so hard,? ht BG:

I live in California, where the Great American Search for Happiness has its headquarters. The notice board of the cafe where I write offers a revolving loop of different paths to bliss: Maum Meditation, TransDance, Chod Training and, most oddly, the drinking of wolf colostrum. Customers jot down the phone numbers earnestly, although statistically they?d be better off joining the Republican Party.

The people taking part in ?happiness pursuits,? as a rule, don?t seem very happy. At the one and only yoga class I attended, shortly after arriving in the United States, the tension and misery in the room were palpable. Which makes sense, because a person who was already feeling happy would be unlikely to waste the sensation in a sweaty room at the Y.M.C.A., voluntarily contorting into uncomfortable positions. The happy person would be more likely to be off doing something fun, like sitting in the park drinking.

Since moving to the States just shy of a year ago, I have had more conversations about my own happiness than in the whole rest of my life. The subject comes up in the park pushing swings alongside a mother I met moments before, with the man behind the fish counter in the supermarket, with my gym instructor and with our baby sitter, who arrives to put our son to bed armed with pamphlets about a nudist happiness retreat in Northern California. While the British way can be drainingly negative, the American approach to happiness can spur a debilitating anxiety. The initial sense of promise and hope is seductive, but it soon gives way to a nagging slow-burn feeling of inadequacy. Am I happy? Happy enough? As happy as everyone else? Could I be doing more about it? Even basic contentment feels like failure when pitched against capital-H Happiness. The goal is so elusive and hard to define, it?s impossible to pinpoint when it?s even been achieved ? a recipe for neurosis.

Happiness should be serendipitous, a by-product of a life well lived, and pursuing it in a vacuum doesn?t really work. This is borne out by a series of slightly depressing statistics. The most likely customer of a self-help book is a person who has bought another self-help book in the last 18 months. The General Social Survey, a prominent data-based barometer of American society, shows little change in happiness levels since 1972, when such records began. Every year, with remarkable consistency, around 33 percent of Americans report that they are ?very happy.? It?s a fair chunk, but a figure that remains surprisingly constant, untouched by the uptick in Eastern meditation or evangelical Christianity, by Tony Robbins or Gretchen Rubin or attachment parenting. For all the effort Americans are putting into happiness, they are not getting any happier. It is not surprising, then, that the search itself has become a source of anxiety.

This is true in my own experience. Even adjusting for emotional openness, my American friends are certainly no happier, and in many ways more anxious than my British ones. For those of us who like their rash assertions to be backed up by meaningless numbers, Britain consistently scores higher on international happiness indexes than the States, although the mental gymnastics required to comprehend a meaningful difference between, say, 74th and 114th place in the world happiness hit parade are probably not a great use of anyone?s time.

So here?s a bumper sticker: despite the glorious weather and spectacular landscape, the people of California are probably less happy and more anxious than the people of Grimsby. So they may as well stop trying so hard.

Source: http://www.mbird.com/2012/09/transdance-california-and-the-great-american-search-for-happiness/

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Spending Time With the Kids by Getting Out of the House | Dadding

store1 300x300 What Kids, Parenting, and Best Buy all Have in CommonI grew up in a neighborhood where my parents could let all of us kids out of the house and into the neighborhood without many fears of bad things happening. My sisters and I all had friends up and down that street and we all got along and we all spent most of our days outside.

That doesn?t seem to be the case anymore. We can let Addie loose out into the circle and occasionally we let her walk two houses further to one of her friend?s houses, but for most of the time we have to be with Addie and Vivi when they want out of the house. Just as it is important that Casey get out of the house on occasion, it is probably even more important that our kids get out of the house as well. For both their sakes?and my sake.

Here?s what I have noticed during my stints as a temporary single parent over the past year. Taking the kids, especially Vivi, to the park or even just to the store makes parenting much easier. Sure, there?s the initial packing everything into a diaper bag and loading the kids into the car, which can be a nightmare for parents like me who don?t do the packing and loading thing all that often, but the rewards far outweigh that burden.

Deciding whether to pack up the kids or to sit at home trying to find activities is a pretty easy decision for me, because spending a full day one-on-one with just Vivi can be pretty difficult. The baby (alright, she?s a toddler but I don?t like admitting it) doesn?t like to play with her toys and she gets bored pretty easily, and there?s only so much Sesame Street that she can watch before I feel guilty for plopping her in front of the TV. There are all kinds of easy places that I can take this little one that aren?t even baby or kid oriented that will keep her fascinated and entertained. Using the afternoon to go to a local Best Buy without any real purpose other than to let Vivi play with all the cellphones has been a great way to keep Vivi entertained and to give me some relief from trying to constantly entertain her. Plus, I get to daydream about the TV I have been promising myself for the last three years that I will eventually buy and put in my family?s loft (or my bedroom).

I?ve also taken the kid to Walmart so we can take a walk down the Oreo Cookie aisle followed by a little stop in the toy aisles. It has always worked like a charm and Vivi comes away entertained and I usually end up with Oreo Cookies, that?s what we call a win/win. (Unless those Oreo Cookies are the new Candy Corn Oreos, those aren?t nearly as good as I expected them to be.)

The Best Buy strategy hasn?t always worked with Addie however, because she isn?t interested in playing with all the cellphones at Best Buy. She already knows the cellphones at the store aren?t toys and she doesn?t care about the latest and greatest in TV land. In fact, she hates going to what she calls the ?daddy store.? When that happens I just adjust and we take a trip to a pet shop, the Humane Society, or a Halloween store. Addie gets some time out of the house and away from the TV, and I get to decide which mask I?m going to secretly buy so I can scare the crap out of Addie when I wake her up for school on Halloween morning.

Read more about my family on?Moosh in Indy or follow me on?Twitter!

Keep up with the latest updates from Dadding ? follow us on?Facebook and Twitter!

More on Dadding:

Zombies, Werewolves, Mummies, and Car Rides with My Family

My Marriage and Life as a Swamper

Creative Parenting 101: I Whistle for My Kids When I Need Them

The Weirdest Food Combinations I Eat as Declared by My Wife

 What Kids, Parenting, and Best Buy all Have in Common

Source: http://blogs.babble.com/dadding/2012/09/24/what-kids-parenting-and-best-buy-all-have-in-common/

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Mexico labor bill would loosen hiring, union grip

FILE - In this May 1, 2012, file photo, a demonstrator holds up a statue depicting Mexican actress Angelica Rivera, center, wife's of Enrique Pena Nieto, then presidential candidate for the Institutional Revolutionary Party (PRI), during a Labor Day march in Mexico City. Most Mexicans agree the country's dysfunctional labor laws need to be retooled. What they don't agree on is how, with a new proposal to loosen work rules and increase union democracy threatening to create the first big political battle for President-elect Enrique Pena Nieto. At left, another demonstrator holds a statue depicting Pena Nieto. (AP Photo/Dieu Nalio Chery, file)

FILE - In this May 1, 2012, file photo, a demonstrator holds up a statue depicting Mexican actress Angelica Rivera, center, wife's of Enrique Pena Nieto, then presidential candidate for the Institutional Revolutionary Party (PRI), during a Labor Day march in Mexico City. Most Mexicans agree the country's dysfunctional labor laws need to be retooled. What they don't agree on is how, with a new proposal to loosen work rules and increase union democracy threatening to create the first big political battle for President-elect Enrique Pena Nieto. At left, another demonstrator holds a statue depicting Pena Nieto. (AP Photo/Dieu Nalio Chery, file)

(AP) ? A proposal to reform Mexico's dysfunctional, 1970s-era labor laws, loosen work rules and increase union democracy split Mexican political parties Tuesday, threatening to create the first big political battle for President-elect Enrique Pena Nieto.

Advocates say the reform, which will allow part-time work, hourly wages and outsourcing, will help Mexico create the million new jobs per year it needs for young people and migrants returning from the United States. The bill weakens seniority provisions, and leaves unchanged Mexico's 5 ?-day work week.

But critics say that Pena Nieto's Institutional Revolutionary Party, the PRI, has stripped out specific requirements for external audits of union finances and secret ballots for union elections contained in the original bill submitted by President Felipe Calderon earlier this month.

Pena Nieto, who takes office on Dec. 1, supports labor reform, but his PRI party ? the largest voting block in Congress ? counts some of the country's most antiquated, autocratic unions among its strongest supporters, leading to speculation that the old guard had pressured his party to leave out what critics say is the only progressive part of the bill. That would weaken Pena Nieto's claims that his party has left behind the reputation of repression and corruption it built up over 71 years in power, from 1929 to 2000.

"They are leaving out the points they claimed were the most beneficial in terms of democracy and transparency, because it's clear there was an agreement between the PRI and (Calderon's) National Action party to move forward on what they're really interested in, which is flexibilized work rules," said Manuel Oropeza, leader of the leftist Democratic Revolution Party, the PRD, in Mexico City.

PRD officials have said they will use any means necessary, including marches, to head off passage of the bill. Even Calderon's normally conservative, pro-business party wasn't happy with the watered-down language on union democracy.

Mexican unions are, at present, so undemocratic that, when opening new plants, employers will sometimes select a docile union for the new facility, and the first workers will enter with a labor contract already signed behind their backs. Many workers don't even know the name of the union that supposedly represents them, and takes their dues.

PRI Congressman Hector Gutierrez said the democracy language had to be changed, because the provisions in Calderon's original bill allegedly violated constitutional articles that protect unions against outside interference.

"It wasn't just a question of a whim," said Gutierrez.

Opponents say Mexico's low wages in several industries already make its labor force more attractive than increasingly affluent countries like China and the last thing its workers need is a reform that would pare the meager benefits and job security they currently enjoy.

"Yes, we need a reform that allows labor productivity to increase, but not at the cost of workers' rights," said PRD national leader Jesus Zambrano.

Congresswoman Luisa Maria Alcalde Lujan of the small leftist Citizen's Movement party said new rules wouldn't create stable new Jobs, but rather "short-term Jobs for a few months with low wages and no benefits."

The problem is pressing: The country's 5.4 percent unemployment rate is probably a huge understatement, given the lack of unemployment insurance and the fact that jobless workers quickly slip into Mexico's vast, unregistered army of street vendors and day laborers. Officials say the lack of jobs is one reason why so many youths are drawn to Mexico's violent drug cartels.

Under Mexico's 1970's-era labor laws, workers earn as little as 60 pesos ($5) per day but still pay dues to pro-company "paper" unions they never see. About one-fifth of salaried workers in Mexico are unionized.

Bosses, meanwhile, complain that expensive severance and benefits packages, along with strict work and seniority rules, make it hard to create new jobs.

Added to that is a lengthy and arcane dispute resolution process that can hold up back-pay or severance cases for a decade.

Experts say loosening work and seniority rules to let employees perform different tasks and gain promotion based on ability would increase productivity.

In August, OECD Secretary General Angel Gurria said that labor reform, together with tax and other changes, could boost Mexico's GDP growth by 1 percentage point per year.

Jaime Moreno, 42, a secretary at a Mexico City high school and part of the National University Workers Union, took part in a protest against the proposed reform last week, saying it would result in a "total transformation of labor relations," with temp labor agencies contracting workers for a few months, without the health, pension and housing benefits most workers currently get.

But business groups say the reform is necessary.

"A flexible labor market, that gives legal certainty to employers and employees, is indispensable if we want our economy to grow," said Alberto Espinosa, leader of the Mexican Employers Federation.

Calderon said the new law, by providing training, probationary and part-time work, could especially help create jobs for those who currently have the hardest time entering the labor market: women and young people.

But critics say Mexico's ongoing wave of drug violence, extortion and robbery of freight shipments play a greater role than labor rules in limiting investment here.

"Businessmen don't avoid hiring people in Mexico because it's expensive," labor lawyer Arturo Alcalde notes, "because they earn so much less."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2012-09-25-Mexico-Labor%20Reform/id-f0eea9e4741b4ae68c321ca7522ac443

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Gas prices dip, but are still pretty high. Should Obama be worried?

Suburban commuters are considered an important constituency this election year, analysts say, and high gas prices are on their list of complaints. Belatedly, they could be beginning to fall.

By Ron Scherer,?Staff writer / September 24, 2012

Gasoline drips off a nozzle during refueling at a gas station in Altadena, Calif., in this March 24 file photo.

Mario Anzuoni/Reuters

Enlarge

There is probably no one watching the gasoline price trends more closely than the Obama campaign.

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That?s because when it comes to everyone?s personal economic indicator, there is nothing quite like the price at the pump.

Almost everyone knows what they paid for their last fill-up, and consumers have a rough idea of what fuel should cost at any given time of year.

What?s more, high fuel prices often result in more than grumbling: consumers cut down on discretionary items such as ice cream or trips to visit friends.

The bad news for President Obama is that suburban commuters, who are especially sensitive to higher gas prices, are part of what analysts say is an important constituency this election year. The good news is that on Monday, prices at the pump were a nickel a gallon less than they were last week, according to the AAA automobile club.

Nevertheless, at $3.81 a gallon gas is still relatively expensive for this time of year. And prices are fairly close to where they were in 2008 when they hit as high as $3.86 a gallon on Sept. 17 of that election year.

?Consumers are not used to seeing gasoline prices this high, this time of year,? says Patrick DeHaan, a Chicago-based senior petroleum analyst at GasBuddy.com, an on-line source of gas prices. ?If you?re not feeling good at the pump, you?re not feeling good in your wallet.?

High gasoline prices are especially noticeable in some key swing states: Michigan ($3.90 a gallon), Wisconsin ($3.90), Pa. ($3.90) and Iowa ($3.82). ?There have been pipeline outages, refinery blips ? it?s been a hard year for motorists in the Midwest,? says Mr. DeHaan.

High fuel prices are also sapping the pockets of the poor, who tend to vote Democratic, and are probably irritating commuters, who are critical swing voters.

But, will voter unhappiness at the pump translate into votes for Mitt Romney?

?Historically, high gas prices have been bad for incumbent presidents,? answers Herman Schwartz, a professor of politics at the University of Virginia.

For example, there have been five elections where gas prices may have had an impact: in 1976, when Gerald Ford lost to Jimmy Carter; in 1980, when Mr. Carter lost to Ronald Reagan; in 1992, when George H.W. Bush lost to Bill Clinton; in 2000, when Al Gore lost to George W. Bush; and in 2008, when John McCain lost to Obama.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/rLtudk0HqeY/Gas-prices-dip-but-are-still-pretty-high.-Should-Obama-be-worried

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Monday, September 24, 2012

11 factors that affect your car insurance rates | Michigan Auto Law Blog

Sorry, Readability was unable to parse this page for content.

Source: http://www.michiganautolaw.com/auto-lawyers-blog/2012/09/24/11-factors-that-affect-your-car-insurance-rates/

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Vegetarian Recipe: Tomatillo Husk Tea | Good Food

Home ? Recipes

24 September 2012 18 views No Comment

Every week on the Good Food Blog we celebrate?Meatless Monday?by sharing a vegetarian recipe from our archives.

Lompoc farmer Mario Trevino?grows tomatillos (small citrusy tomato-like fruits with a hard protective husk)?and talks about the medicinal properties of the husk (he makes a medicinal tea out of the tomatillo husk to lower his blood sugar). It tastes awful, but Mario says it?s brought his blood sugar down significantly.? He first shared this recipe for?Tomatillo Husk Tea?on September 29, 2007.

?

Keep reading for the full recipe?

Tomatillo Husk Tea
10 tomatillo husks
1 zucchini
1 nopal cactus

Boil for an hour and a half. Let it sit overnight. Drink the following morning.

?

?

Source: http://blogs.kcrw.com/goodfood/2012/09/vegetarian-recipe-tomatillo-husk-tea/

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Sunday, September 23, 2012

Dell releases new S Series monitors with edge-to-edge glass, IPS panels

Dell releases new S Series monitors with edgetoedge glass, reasonable price tags

Dell's built quite a reputation for delivering solid monitors at reasonable prices, and it's now expanded its offerings in a fairly big way with no less than five new S Series models, some of which boast edge-to-edge glass and/or IPS panels. On the top end is the 27-inch S2740L, which has the most connectivity options of the lot (DVI, VGA, HDMI and a pair of USB ports) and, of course, the highest price tag at $400. From there, things drop to $300 with the 24-inch S2440L (the only non-IPS model of the lot), and go all the way down to $200 for the 21.5-inch S2240M -- the three lower-end models ditch the edge-to-edge glass but still retain minimal bezels. Unlike some of the company's higher-end UltraSharp models, though, all five monitors have a 16:9 aspect ratio instead of 16:10, and you'll get a standard 1920 x 1080 resolution regardless of the size you choose. Complete specs for each can be found at the links below.

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